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If nausea persists beyond two weeks, your dose may be too high

A Cochrane Review of vitamin and mineral supplements to maintain cognitive function in cognitively healthy people included 14 studies that compared folic acid, vitamin B12, vitamin B6, or a combination of these supplements to placebo in 27,882 participants, most of whom were age 60 years or older [97]

**Skipping the room-temperature step:** Cold powder dissolves poorly and may leave undissolved particles that look like contamination

Side effects and what to expect at different doses The 60 mg vial does not change the side effect profile

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