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Description

Overall, we confirmed that HuR binds to intron 14 of GLS , favors the KGA isoform during splicing, binds to the 3-UTRs of GAC and KGA, increases KGA and GACs mRNA stability and potentially controls the translation of both isoforms

Cell 40, 205215

Tejero et al

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The link with lipid metabolism has been provided by employing a siRNA for OCTN2, which lowered carnitine uptake triggering an increased formation of lipid droplets and a decreased cell proliferation