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Responses to K deficiency and waterlogging interact via respiratory and nitrogen metabolism

Reactive oxygen and nitrogen species (ROS/RNS) play a signaling role in a healthy heart, but an excessive and unregulated production of these molecules can lead to oxidative stress and damage to cardiomyocytes

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Paradigms, such as CUMS or CSDS, are useful for probing mechanisms, but they capture only fragments of the human condition and cannot fully reproduce the complexity of real depressive or addictive states 185