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Norepinephrine, serotonin and dopamine are neurotransmitters in the hypothalamus (the appetite center), which is thought to play a role in energy intake, energy expenditure, substrate utilization, and adipose storage

When older, first-generation peptides bind to the ghrelin receptor, they possess what scientists call a "broad binding affinity." They flip the main Growth Hormone switch, but their bulky chemical structure accidentally bumps into the Cortisol and Prolactin switches at the same time

doi: 10.1093/carcin/9.5.823 146 MontanoL.PirontiC.PintoG.RicciardiM.BuonoA.BrognaC.et al

This delivery method allows the peptide to reach cartilage tissue at effective concentrations while minimizing systemic exposure

Do not apply to irritated, broken or sensitive skin