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High-dose therapy with cyclophosphamide can lead to organ damage, including GI ulceration, cystitis (see next paragraph), and, less commonly, pulmonary, renal, hepatic, and cardiac toxicities (a hemorrhagic myocardial necrosis)

44 , W90W97 (2016)

It has been shown that liver enzymes, including alanine transaminase (ALT) and aspartate transaminase (AST), are significantly higher in G6PD-deficient patients than in unaffected individuals [65]

The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity

Glutathione supports immune cells and helps regulate inflammation so the body can respond without overreacting