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Methods Gene expression profiles were downloaded from the Gene Expression Omnibus, and batch-corrected and normalized expression data were obtained using the ComBat package

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Studies indicate that diminished VEGF expression precipitates neurodegeneration by compromising neural tissue perfusion, thus exacerbating neuronal vulnerability to ischemic insults and metabolic imbalances (Oosthuyse et al

*Correspondence: Lei Huang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers