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doi: 10.1371/journal.pone.0172486

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The hallmarks of ferroptosis Ferroptosis is a cell death pathway that has been the focus of increasing investigation due to its theorized role in numerous human diseases

Recent studies in solid cancers have found that APR-246 can also induce p53-independent cell death

Therefore, we aimed to identify factors affecting PK variability of busulfan in pediatric allogeneic hematopoietic cell transplantation (HCT) recipients and investigate the effect of glutathione S-transferase (GST) activity on busulfan metabolism using a semi-mechanistic population PK model