5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation (94)
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doi: 10.1038/nm.3145 114 KoliadaA.SyzenkoG.MoseikoV.BudovskaL.PuchkovK.PerederiyV.et al (2017)
Acta Neurol Scand
