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Conclusions Oxidative damage plays a pivotal role in disrupting the BBB, significantly contributing to the pathogenesis of neurodegenerative diseases by promoting neuroinflammation and neuronal injury through the influx of blood-derived proteins into the brain (Figure 4)

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Once released into the extracellular space, especially after tissue injury, they undergo changes from reducing to oxidizing environments that alter their function, associated with mitochondrial dysfunctions

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