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(2) Multi-target convergence integrates complementary mechanisms: (i) CLEC-2 inhibitors disrupt thrombo-inflammatory cascades [120, 121], (ii) PL720 nanocarriers deliver arginine/FTY720 to reprogram macrophages and accelerate inflammation resolution [122], and (iii) anti-CXCR2 [RBC-P]NPs suppress p38 (Mapk14)-mediated M1 polarization to halt atherosclerotic plaque progression [99, 100]