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According to the landscape document from the WHO, COVID-19 vaccine candidates generally fall into seven strategies (Box 1), which can be divided into three broad categories 44 : first, protein-based vaccines that generate target antigens in vitro such as inactivated virus vaccines, virus-like particles and protein subunit vaccines

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2.3 Role of mitochondria in disease progression Disease progression is a central theme in human pathology and is the overwhelming determinant in the morbidity and mortality associated with all diseases, especially those associated with chronic inflammation