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While M1-activated microglia are indeed associated with cytotoxic responses through mechanisms such as nitric oxide release, M2 cells promote tissue repair via secretion of trophic factors like IGF-1, GDNF, and transforming growth factor- [469471]

Zinc deficiency is related to increased susceptibility to various pathogens, resulting in dysfunctional humoral and cell-mediated immunity

Thus, there was the absence of pronounced CVDs in a majority of K3 patients with a significantly lower frequency of parkinsonism (chronical tremor and akinesia rigidity syndrome)

10.7554/eLife.26850 eLife 60 DicksonD

The effects included the release of ATP, cGAMP, and HMGB1 into the extracellular space