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A number of studies report that flavokavains A and B are the most cytotoxic compounds identified in kava [152], and one study particularly demonstrated its toxicity towards cells of liver origin and showed that they increased the cellular level of AST, indicative of potential liver toxicity [188]

Therefore, the anti-inflammatory actions of low-to-moderate dose of corticosteroids are potentially protective to critically ill COVID-19 patients (Shang et al., 2020)

[33] [32] Alternative causes of this tissue damage have been proposed

In addition, it is often cumbersome and inconvenient to have to count/calculate how many micrograms are in each serving we eat, take several doses a day to optimize absorption and release FI saturation, etc