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Salusin-, a bioactive peptide containing 20 amino acids, is translated from the alternatively spliced mRNA of the torsion dystonia related gene (TOR2A)[156]

Based on the plethora of symptoms affecting different organs/systems, PASC-affected population could be categorized into four different clusters or sub-phenotypes: Sub-phenotype-1 (33.8%) with cardiac and renal manifestations, Sub-phenotype-2 (32.8%) with respiratory, sleep and anxiety disorders, Sub-phenotype-3 (23.4%) with skeleton-muscular and nervous disorders, and Sub-phenotype-4 (10.1%) with digestive and pulmonary dysfunctions 123,136

Armed with the above data, which have recently come to light, we are now in a position to identify alterations possibly taking place in pathological pregnancies, ranging from tubal pregnancies to recurrent spontaneous abortions

Finally, conducting large-scale clinical trials of the optimized nanosystems loaded with conventional PD drugs and/or phytochemicals would be essential