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7.2 Anti-synuclein aggregation therapy (ASAT) -synuclein is an unfolded highly soluble protein that is found in presynaptic neurons throughout the brain [47]

Free Radical Biology and Medicine 122: 137-149

Moreover, by integrating Limited Proteolysis-Small Molecule Mapping, western blotting and siRNA-based functional assays, we identify that uridine binds to poly(rC)-binding protein 1, thereby suppressing ferroptosis and preserving mitochondrial function

The study employed rotenone (3 mg/kg/day for 21 days) administered via intraperitoneal injection to establish a rat model of PD, with hydrogen-saturated saline (0.6 mM) applied at different stages (early, middle, late) for treatment