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Stopped-flow kinetic measurements For all stopped-flow measurements, freshly purified proteins were reduced with 5 mM DTT on ice for 30 min

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Deficiency of folate contributes to a higher homocysteine level, thus leading to increased cytosolic calcium and reactive oxygen species (ROS) 31

Over the previous decades, nanotechnology has gained much importance as a revolutionary approach to combat cancer owing to the unique properties of NPs, such as their size, shape, large surface-to-volume ratio, tunable surface chemistry, and the ability to encapsulate/carry and deliver various drugs, that confer to them many advantages over their bulk counterparts [516]