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Why is AOD-9604 supplied as a lyophilized powder rather than a pre-mixed solution

Cryo-EM grid preparation and data collection For the cryo-EM grids preparation, 3 l of purified ghrelin-bound complex at 13 mg/ml and GHRP-6-bound ghrelin receptor complex at 8 mg/ml were applied individually onto a glow-discharged holey carbon grid (Quantifoil, Au300 R1.2/1.3) in a Vitrobot chamber (FEI Vitrobot Mark IV)

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In parallel, photoswitchable PROTACs (PS-PROTACs) achieve reversible modulation of degradation activity by integrating moieties, typically azobenzene derivatives, that undergo light-driven isomerization [146, 147]