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Thus, while the molecular mechanism of PINK1 activation by MTK458 remains unclear, these assays demonstrate the usefulness of chemical probes in dissecting the molecular mechanisms of drugs and the robustness of PRT062607 as an inhibitor of PINK1

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Zeng C, Qiu Y, Li S, Teng Z, Xiang H, Chen J, et al

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163, 164 A summary of the exogenous antioxidant mechanisms that likely account for their anti-hypertensive effects is shown in Table 1 and Figure 2