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The SAH gets reversibly hydrolyzed to homocysteine and adenosine via SAH hydrolase (SAHH) activity

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This is consistent with our model that the decrease in itaconate and succinate is caused by NO-driven PDHC and OGDC inhibition, and is consistent with data showing that PDHC and OGDC activity and carbon incorporation from glucose and glutamine into the TCA cycle are rescued by iNOS knockout (Fig

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doi: 10.1016/j.ejphar.2023.175881 44 LiuX.ShanX.ChenH.LiZ.ZhaoP.ZhangC.et al