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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

Furthermore, CYP-generated eicosanoids likely are involved in more diverse physiological responses than previously appreciated

Detoxifying the skin: It helps flush out toxins from the body, leading to a clearer complexion

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

This can be from direct alkylation of cysteine residues in the bladder by the glutathione adduct or acrolein that is reformed in the bladder