napqi glutathione mechanism File:Acetaminophen metabolism.jpg GSH reduces NAPQI, the metabolite

GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective PMC The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets PMC Simplified scheme of APAP metabolism, leading to the formation of NAPQI Download Scientific Diagram

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