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Oral administration is physically possible, but without bioavailability data, there is no way to determine an effective oral dose or confirm that the compound is reaching target tissues

This allowed for a natural experiment

Archer SL , Huang JM , Hampl V , Nelson DP , Shultz PJ , Weir EK

The 50 and 130 kDa low-molecular-weight forms specifically produced significant wrinkle-depth reduction by mean roughness (Ra) and maximum roughness (Rz) measurement, attributed to deeper dermal penetration of the smaller molecules [7]

Unlike oral supplements that may have limited absorption, IM injections ensure 100% bioavailability of this vital nutrient that's crucial for red blood cell formation, nerve function, DNA synthesis, and overall metabolic health