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Kynurenine production insufficiency theory Recent research has identified the aryl hydrocarbon receptor (AhR) and the enzyme indoleamine-2,3-dioxygenase (IDO) as key players in the increased gut permeability and bacterial endotoxin translocation seen in ME/CFS patients

Il est conseill dviter les fortes doses de vitamine B6 (28)

*The main intake mechanism via intrinsic factor is limited to 1.5 g/dose

Avoid heavy meals or alcohol around therapy time for the best results

The combination therapy showed slightly better scores in WOMAC and Lequesne indices than HA alone, but not enough to support strong clinical superiority (Nouri et al., 2022)