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The research conducted by Ruiz-Canela et al (148) has proved a significant correlation between plasma levels of BCAAs and the risk of CVDs, but the limitations of observational studies, such as confounding factors related to diet and physical activity, affect the robustness of this relationship

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In African regions with high HIV prevalence, ISs use presents additional challenges, as it may worsen immune suppression and complicate HIV treatment

5 Nonpharmacologic treatments first Once the diagnosis of POTS is established, initial treatment is aimed at reducing symptoms, improving quality of life and educating the patient