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In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]

Thirty-two male mice were started on a 60% high-fat diet of 5.24 kcal/g at three weeks of age for 19 weeks, followed by a 45% HFD of 4.73 kcal/g for six additional weeks

Disclosure of interest: Satoshi Namitome: nothing to disclose

Flow cytometry using the DCFH-DA probe indicated that the marked elevation in ROS levels caused by the OGD and erastin treatments was rescued by the GSH treatment (Fig

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