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doi: 10.1016/j.addr.2022.114296 [DOI] [PubMed] [Google Scholar] 41

MOTS-c acts as a metabolic coordinator, linking mitochondrial health to nuclear gene expression, a critical communication system that often fails during aging and metabolic disease

Upon stimulation, these neurons secrete their respective hypothalamic-releasing hormones into the hypothalamic-adenohypophyseal plexus, which flows to the anterior pituitary gland