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Effective poly(amidoamine) (PAMAM) dendrimers enhance transdermal permeation, enabling specific drug targeting through surface and generation modifications [200]

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Intramuscular injection, by contrast, deposits peptide 1540mm deep (depending on needle length and injection site), requiring the compound to enter venous return, circulate systemically, and then diffuse back out of dermal capillaries to reach fibroblasts