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Rectal tumour biopsies ( n =10) were collected from consenting patients undergoing diagnostic endoscopy, a baseline measurement of metabolic rate was recorded, biopsies were treated for 24 h with metformin (10 mM) or H 2 O vehicle control and metabolism was assessed at 24 h post treatment

Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions

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Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo