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While he consistently emphasizes that adequate sleep, sunlight exposure, exercise, and nutrition should take priority, when these foundational elements are in place, using supplements may help optimize physiological function for longevity

Given the strong association between glutathione depletion and the progression of mitochondrial diseases, dietary supplements with the potential to increase intracellular glutathione reserves have been the subject of much research in recent years [11]

J.HawkerC

Systemic bioavailability of orally consumed glutathione is low because the molecule, a tripeptide, is the substrate of proteolytic enzymes (peptidases glutamyl transpeptidase GGT) of the alimentary canal, and because of the absence of a specific carrier of glutathione at the cell membrane site

One such indicator is elevated Gamma glutamyltransferase (GGT), the enzyme that breaks down glutathione from the blood to allow its importation into the cells