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FDA staff found inadequate characterisation, no evidence supporting insomnia effectiveness and no clinical safety data

Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus

The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)