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FIGURE 1 Overview of the Mitochondrial Biogenesis Mitochondria are double membrane-bound organelles, especially with the generation of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) being one of their main functions

Subject: A "subject" may include a human subject for medical purposes, such as for the treatment of an existing disease, disorder, condition or the prophylactic for preventing the onset of a disease, disorder, or condition or an animal subject for medical, veterinary purposes, or developmental purposes

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Internalized CIRP effectively blocks the interaction between ZBP1 and tripartite motif-containing 32 (TRIM32), an E3 ubiquitin ligase targeting ZBP1 for proteasomal degradation, thereby enhancing ZBP1-dependent PANoptosis of PVECs and exacerbating ALI in sepsis