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The authors declare that they have no competing interests.

Under catabolic conditions in cancer, arginine levels in plasma are decreased, as observed in patients with breast cancer, colon cancer, and pancreatic cancer, independent of weight loss or tumor stage (Vissers et al., 2005)

In conclusion, our study focused on unravelling the regulation of the GABAergic pathway in SMA, providing new evidence supporting the involvement of the cortical motor network in exacerbating disease progression through E/I imbalance, while also linking SMA to other neurodegenerative movement disorders

For adults, the recommended intake is 425 milligrams (mg)/day for women and 550 mg/day for men

In a randomized crossover trial of healthy adults, 1 week of magnesium supplementation enhanced brachial artery flow-mediated dilation, while in vitro research shows that low-magnesium conditions downregulate endothelial NO pathways and upregulate pro-oxidant signaling ( 4.5 Arrhythmias and acute indications Intravenous magnesium sulfate remains a guideline-endorsed treatment for torsades de pointes and is part of the Advanced Cardiovascular Life Support protocol