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Okafo, G., Prevedel, L

Overexpression of glutathione peroxidase 4 (GPX4) reduced oxidative damage markers but disrupted the physiological balance of mitochondrial redox homeostasis in aged mice, suggesting that antioxidant interventions require careful regulation to avoid disrupting normal metabolism (80)

Even though total GST activity in the liver was measured, we specifically inhibited GSTP1 isoform, not the broader GST enzyme family

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Glutathione is a substance that can inhibit the bodys natural production of melanin, the pigment that gives our skin its color, produced by activation of the enzyme Tyrosinase