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It is speculated that iron deficiency may limit the activity of iron-dependent tyrosine hydroxylase, thereby weakening dopaminergic signal transmission, which is also a core pathophysiological feature of ADHD

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Activation of the TLR1/2 signaling pathway by the TLR1/2 agonist bacterial lipoprotein (BLP) inhibits M-MDSC-mediated immunosuppression by promoting their differentiation into M1 macrophages in a murine model of lung cancer, marked by decreased ARG1 and CD206 levels (154)