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The distribution of fibrosis stages was F0 67 (14.6%), F1 91 (19.8%), F2 129 (28.0%), F3 134 (29.1%), F4 39 (8.5%)

Studies have shown that TCM (natural medicine extracts, Chinese herbal formulas and proprietary Chinese medicines) can effectively modify the host intestinal flora structure and its metabolite levels, repair the intestinal mucosal barrier, reduce inflammatory infiltration, as well as regulate lipid metabolism-related pathways and genes expression to correct LMD (Figure 2)

To overcome these constraints, we propose that future prospective studies implement three key strategies: (1)Systematic collection of dietary and supplemental B12 data using standardized instruments such as food frequency questionnaires

Both LSG and RYGB significantly reduced mortality risk compared to MOVE

Furthermore, IV therapy increases the bioavailability and therapeutic effectiveness of medications