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Administering our novel and patented combination of a more collagen-mimicking ratio [3 Gly : 1 Pro : 1 Hyp] as a tool compound in preclinical models and then optimization by adding supporting ingredients (alpha-ketoglutarate, astaxanthin, and vitamin C) showed improvements in skin features and reduced biological age by 1.33 years in women and 1.48 years in men (pooled mean difference 1.37