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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

This inability to maintain immunological homeostasis in the gut encourages the entry of luminal antigens into underlying tissues where excessive inflammatory responses are induced further (Knig et al

A.KuzmiskiJ

2019 Aug 30;7(18):3101-3105

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