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PNAS 106 , 26882693 (2009)

Methods: A cross-sectional analysis of patients referred to the Non-Alcoholic Fatty Liver Disease (NAFLD) clinic at an academic center in Ontario, Canada

Formation of reactive metabolites: Many hepatotoxicants like carbon tetrachloride [59], amodiaquine [60], acetaminophen [61], halothane [42], isoniazid [62,63] allyl alcohol and bromobenzene are metabolically activated to chemically reactive toxic metabolites which can covalently bind to crucial cellular macromolecules thus inactivating critical cellular functions [6]