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By integrating mechanistic, preclinical, and clinical evidence, this review seeks to position capsaicin as a plausible natural multitarget therapeutic candidate and to provide a conceptual framework for future interventions targeting the complex pathophysiology of CMS

It is often combined with platinum-based chemotherapy regimens for the treatment of various malignancies (69)

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Based on these limitations, we propose critical unresolved questions and outline promising research directions in this area

Dietary Restriction and Fasting Dietary restriction and fasting lead to a significant increase in pituitary secretion of GH (508)