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Endocr Relat Cancer (2012) 19(5):F18

Phase I trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) for brainstem recurrent glioma

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To enable comparison of the binding of Pt(II) to various positions in the four nucleobases in DNA and to keep computational costs to a minimum, Pt(NH 3 ) 3 2+ was used as the fragment that interacted with the bases