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Retrieved 22 December 2015

Reduced GCLC promoter activity from this variant produces a lower basal GCLC enzyme pool constraining the rate of -GluCys synthesis from the transcriptional level, upstream of any allosteric or substrate-availability-related regulation

[7] [29] [30] Ketoconazole Due to its potent inhibition of the hepatic isoenzyme CYP3A4, oral ketoconazole coadministration with other drugs metabolized by CYP3A4 should be done with extreme caution, if at all

However, they observed that due to the low methodological quality and the small number of studies included some cautions must be considered with these results