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Y.JaiswalA.ShahD.SalveJ.et al (2024)

93 Additionally, mTORC1 activity is suppressed during amino acid deprivation because RAP1 GTPases promote lysosome repositioning to the perinuclear region and reduce lysosomal abundance

Mol Med Report , 2018, 17: 58215829 Holman GD

Of particular interest, IFN- levels rose following treatment, implying a potential recalibration toward enhanced immune surveillance rather than a mere pro-inflammatory rebound (37)