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Caudevilla, D

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In addition, ongoing research efforts are exploring the potential of MOR202 for treating membranous nephropathy (NCT04145440), while TAK79 is being investigated for conditions like severe systemic lupus erythematosus and myasthenia gravis (NCT04159805)

LRRK2 is located mainly in the cytoplasm, although approximately 10% of LRRK2 is located to the mitochondria and regulates mitochondrial function ( LRRK2 mutations in DA neurons were associated with an increased susceptibility to oxidative stress ( VPS35 Vacuolar protein sorting 35 (VPS35), composed of 796 amino acids, is a core component of the retromer complex and participates in endosomal-lysosomal transport