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In the myocardium, a reduction in LOX activity disrupts the connective tissue architecture and impairs contractile function [47]

Finally, membrane lipid composition and more importantly the long polyunsaturated fatty acid (PUFA) is playing a key role in ferroptosis sensitivity

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[DOI] [PubMed] [Google Scholar] 118.Karpusas M., Axarli I., Chiniadis L., Papakyriakou A., Bethanis K., Scopelitou K., Clonis Y.D., Labrou N.E

LCA and DCA are the preferred ligands for TGR5, while CA and CDCA are the most potent FXR ligands [7]