Akkermansia muciniphila supplementation improves PD-1 blockade efficacy in MAFLD-related HCC models by restoring intestinal barrier integrity, lowering LPS and BA metabolite translocation, and reducing suppressive cells (MDSCs, M2 macrophages), thereby enhancing CD8 + T cell infiltration ( + T cell activation ( + T cell exhaustion and impair anti-tumor immunity ( While this review emphasizes BAs, other gut microbiota-derived metabolites (e.g., inosine, short-chain fatty acids) also regulate CD8 + T cells through distinct pathways ( + T cell metabolic circuits remains under investigation ( In summary, BA metabolites from the gut microbiota critically shape CD8 + T cell-mediated anti-tumor immunity and ICI responsiveness
[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Ito M, Miyauchi A, Morita S, Kudo T, Nishihara E, et al
[Abstract] Western blot analysis and densitometric quantification of MT1, Cleaved Caspase-9, Bax, Bcl-2, Cleaved Caspase-3, and Cytochrome c in the testis of SF mice treated with MEL (10 mg/kg
Mounting evidence indicates that PA possesses significant anti-cancer activity in various tumor models ( Ferroptosis, a distinct form of regulated cell death, was first described in 2012 ( 2 Materials and methods 2.1 Cell culture Human normal lung epithelial cells (BEAS-2B) and human NSCLC cells (H1299 and A549) were obtained from the American Type Culture Collection
doi: 10.1093/pcp/pcw158
