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The above findings showed that the body-weight effect of the conjugate can partially be governed by actions in adipose depots because glucagon receptors exist in rodent adipocytes, less than in liver

Conversely, others prefer morning administration to avoid nocturnal gastrointestinal discomfort that might disrupt sleep

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Under the second alternative, which we finalized in section III.A.2 of this rule, we will set the payment limit for a given quarter using the biosimilar's most recently available positive ASP data and either 6 percent (or 8 percent for qualifying biosimilar biologicals) of the amount determined under section 1847A(b)(4) of the Act for the reference biological product (as defined in 414.902) for the given quarter

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