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*Correspondence: Antonio Di Sabatino, [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Research Context NAD acts as a hydride-transferring coenzyme in cellular redox reactions, cycling between its oxidized (NAD) and reduced (NADH) forms within mitochondrial and cytoplasmic metabolic pathways including glycolysis, the citric acid cycle, and oxidative phosphorylation