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Description

Through promoting p38 phosphorylation in the MAPK pathway, TMAO activates inflammatory pathways and upregulates NOX4 to enhance oxidative stress and activate NLRP3 inflammasomes, resulting in renal inflammation

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If taking any medication or if you have a medical condition, consult your healthcare practioner before use

The cumulative transdermal rate (%) was calculated as: where Vi is the volume of the i -th sample aliquot, Ci is the mass concentration of the API in the i -th sample, V is the total volume of the receptor compartment solution, Cn is the API concentration in the n -th sample, and Cm and Vm are the initial API concentration and volume of the medium, respectively