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However, this hypothesis requires further investigations

Absence of cytosolic 2-Cys Prx subtypes I and II exacerbates TNF-alpha-induced apoptosis via different routes

Mansoor MA, Svardal AM, Schneede J, and Ueland PM (1992)

For example, the glutathione conjugate of hexachlorobutadiene is processed in the kidneys into reactive intermediates, leading to nephrotoxicity

PE-AA is a PUFA that can be catalyzed by LOX15 and Fe 2+ to generate oxidized phospholipid ox-PE, thereby participating in the initiation of ferroptosis (Shimada et al., 2016)