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Varani and colleagues at the University of Michigan published a landmark study in 2006 in The American Journal of Pathology showing that fibroblasts 8 Fibroblasts Dermal cells responsible for producing collagen and elastin

5 Disease-Modifying Treatments Despite the rich portfolio of symptomatic approaches to treat the cardinal motor features of PD as well as levodopa-related motor complications there are still major unmet needs in the pharmacological management of progressive motor and non-motor symptoms in the advanced stages of disease [175]